Triterpenes
AssigneeMerck & Co., Inc.
InventorMichael A. Goetz
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Abstract
Four triterpenes of Formula 1 (where "---" is either a single or double bond and R is H or acetate) are disclosed which are potent and selective immunosuppressive agents. These compounds have been isolated from Spachea correa root. ##STR1##
Claims12
A compound of Formula 1 ##STR4## where `---` represents either the presence or absence of a double bond when R is H and `---` represents the presence of a double bond when R is Ac;
- or a pharmaceutically acceptable salt, hydrate or crystal form thereof.
A method of suppressing the immune system in a subject in need thereof, which comprises the administration to the subject of an immune suppressing amount of a compound selected from Formula 1(a), 1(b), 1(c), or 1(d) ##STR5## a pharmaceutically acceptable hydrate or crystal form thereof.
Dependencies are inferred from the claim text.