Perhydroisoindole derivatives, preparation thereof and pharmaceutical compositions containing same

A perhydroisoindole derivative of the formula (I) or salts thereof:

• ##STR8## in which the R groups are identical and represent phenyl radicals optionally substituted with a halogen atom or with a methyl radical in the 2- or 3- position,
• R.sub.1 represents a phenyl radical optionally substituted with one or more halogen atoms or hydroxyl, benzyloxy or alkyl radicals, said alkyl radicals being optionally substituted with halogen atoms or with amino, alkylamino or dialkylamino radicals, or said phenyl radical being optionally substituted with alkyloxy or alkylthio radicals, said alkyloxy, and alkylthio radicals being optionally substituted with hydroxyl, amino, alkylamino or dialkylamino radicals that are optionally substituted with phenyl, hydroxyl or amino, or said alkyloxy and alkylthio radicals being optionally substituted by dialkylamino radical whose alkyl portions form, with the nitrogen atom to which they are attached, a 5- to 6-membered heterocycle that may contain another hetero atom that is oxygen, sulphur or nitrogen, and said dialkylamino radical being optionally substituted with an alkyl, hydroxyl or hydroxyalkyl radical, or said phenyl radical being substituted with amino, alkylamino or dialkylamino radicals whose alkyl portions may form, together with the nitrogen atom to which they are attached, a heterocycle as defined above, or
• R.sub.1 represents a cyclohexadienyl, naphthyl or indenyl radical, or a saturated or unsaturated mono- or polycyclic heterocyclic radical containing 5 to 9 carbon atoms and one or more hetero atoms chosen from oxygen, nitrogen or sulphur, and said cyclohexadienyl, naphthyl, or indenyl radicals being optionally substituted with a halogen atom or with an alkyl, alkyloxy, aminoalkyl, alkylaminoalkyl or dialkylaminoalkyl radical,
• R.sub.2 represents a hydrogen or halogen atom or a hydroxyl, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxyl, alkyloxycarbonyl, dialkylaminoalkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino radical, and
• R.sub.3 represents a phenyl radical optionally substituted in the 2-position with an alkyl or alkyloxy radical containing 1 or 2 carbon atoms,
• the alkyl and acyl radicals recited above being, with the exception of the recited heterocycles, straight or branched and containing 1 to 4 carbon atoms.