Piperidinyl thiacyclic derivatives

A compound of the formula ##STR69## an optical isomer or a pharmaceutically acceptable salt thereof, wherein Y is --C(OH)(phenyl)-- wherein

• Y is attached at the heterocycle position 2 or 3;
• X is carbon, CH or nitrogen, provided that when Y is attached at the 3 position X is carbon, and when Y is attached at the 2 position X is CH or nitrogen;
• R.sub.1 is --(CH.sub.2).sub.n --Z--(CH.sub.2).sub.m COR.sub.5, --C(O)R.sub.8 or ##STR70## R.sub.2 and R.sub.3 are taken together, with the atoms to which R.sub.2 and R.sub.3 are respectively attached, to form a phenyl moiety substituted with R.sub.4 ;
• Z is a bond, O, or S;
• R.sub.4 is hydrogen, chloro, fluoro, C.sub.1-4 alkyl, or C.sub.1-4 alkoxy;
• R.sub.5 is OH, C.sub.1-4 alkoxy or --NR.sub.6 R.sub.7 ;
• R.sub.6 and R.sub.7 are the same or different and are H or C.sub.1-4 alkyl;
• R.sub.8 is C.sub.1-4 alkyl, C.sub.1-4 alkoxy;
• R.sub.9 is H, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, OH, chloro, bromo, fluoro, --CF.sub.3, --NHC(O)R.sub.10, or CO.sub.2 R.sub.11 ;
• R.sub.10 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy;
• R.sub.11 is hydrogen or C.sub.1-4 alkyl;
• n is an integer from 0-3 provided that when Z is not a bond, n is an integer from 2-3;
• m is an integer from 1 to 3;
• d is an integer from 1-5;
• and
• e is zero or 1, provided that when e is 1:
• d is an integer from 2 to 5.