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AssigneeUniversity of Florida Research Foundation, Inc.
InventorsLuiz Belardinelli, Ray Olsson, Stephen Baker, Peter J. Scammells, Peter G. Milner, J urg R. Pfister, George F. Schreiner
Estimating the term…
Xanthine derivatives, and compositions comprising those compounds, are potent selective antagonists of adenosine receptors. The derivatives and compositions are used to treat conditions, including certain cardiac arrhythmias. The compounds, specifically, are C-8 epoxide derivatives of xanthine having the general formulae of: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different, and can be H or an alkyl group of 1-4 carbons, and n=0-4; and ##STR2## wherein R.sub.1 and R.sub.2 are the same or different, and can be H or an alkyl group of 1-4 carbons, R.sub.3 is either O or (CH.sub.2).sub.1-4, and n=0-4.
A C-8 epoxide of xanthine, wherein said xanthine epoxide has a formula selected from the group consisting of:
A method for modulating the biological activity of adenosine wherein said modulation of adenosine is antagonism of adenosine binding with an adenosine receptor, said method comprising administering an effective amount of a compound, wherein said compound has a formula selected from the group consisting of:
A composition for modulating biological activity of adenosine wherein said modulation of adenosine is antagonism of adenosine binding with an adenosine receptor, said composition comprising an epoxide of xanthine and a pharmaceutically acceptable carrier, wherein the xanthine epoxide has a formula selected from the group consisting of:
Dependencies are inferred from the claim text.