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US 5,631,259 AGranted
Cycloalkltriols containing cyclic substituents, processes and intermediate products for their preparation and their use as antiviral and antiparasitic agents
AssigneeHoechst Aktiengesellschaft
InventorsGerhard J ahne, Irvin Winkler, Matthias Helsberg, Heinz H anel
Life of this patent
Estimating the term…
Abstract
Cycloalkyltriols containing heterocyclic substituents, in particular cyclopentyl- and cyclohexyltriols containing heterocyclic substituents Compounds of the formulae I and II ##STR1## in which the substituents A, R.sup.1, R.sup.2 and R.sup.3 and n have the meanings given, have an antiviral and antiparasitic action.
Claims2
A compound of the formula VIIa or VIIIa:
- ##STR11## wherein R.sup.5 is hydrogen n is 1 or 2 and A is
- adenin-9-yl,
- adenin-3-yl,
- {N.sup.6 -(N-methyl-2-pyrrolidin-yliden)}adenin-9-yl,
- adenin-N.sup.1 -Oxid-9-yl,
- hypoxanthin-9-yl
- 6-chlorpurin-9-yl,
- 6-chlorpurin-7-yl,
- adenin-7-yl,
- 6-(2,2-diphenyl-ethylamino)-purin-9-yl,
- 2,6-diaminopurin-9-yl,
- 2-amino-6-mercapto-purin-9-yl
- 2-aminopurin-9-yl,
- guanin-9-yl,
- guanin-7-yl,
- N.sup.2 -acetyl -6-O-di-phenylcarbamoyl-guanin-7-yl,
- N.sup.6 -acetyl-adenin-9-yl,
- 2-acetamido-6-ethoxy-purin-9-yl, or
- N.sup.6 -methyl-adenin-9-yl;
- and when n is 2, A can also be 2-amino-6-chloro-purin-9-yl.
17 more elements
A pharmaceutical composition containing at least one compound of the Formulas VIIa or VIIIa:
- ##STR12## wherein R.sup.5 is hydrogen n is 1 or 2 and A is
- adenin-9-yl,
- adenin-3-yl,
- {N.sup.6 -(N-methyl-2-pyrrolidin-yliden)}adenin-9-yl,
- adenin-N.sup.1 -Oxid-9-yl,
- hypoxanthin-9-yl
- 6-chlorpurin-9-yl,
- 6-chlorpurin-7-yl,
- adenin-7-yl,
- 6-(2,2-diphenyl-ethylamino)-purin-9-yl,
- 2,6-diaminopurin-9-yl,
- 2-amino-6-mercapto-purin-9-yl
- 2-aminopurin-9-yl,
- guanin-9-yl,
- guanin-7-yl,
- N.sup.2 -acetyl-6-O-di-phenylcarbamoyl-guanin-7-yl,
- N.sup.6 -acetyl-adenin-9-yl,
- 2-acetamido-6-ethoxy-purin-9-yl, or
- N.sup.6 -methyl-adenin-9-yl;
- and
- when n is 2, N can also be 2-amino-6-chloro-purin-9-yl;
- or a physiologically tolerated salt of said compound, together with a pharmaceutically acceptable carrier.
19 more elements
Dependencies are inferred from the claim text.