Pyridazine derivatives
AssigneeSanofi
InventorsRobert Boigegrain, Roger Brodin, Jean P. Kan, Dominique Olliero, Camille G. Wermuth
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Abstract
The present invention relates to pyridazine derivatives of formula: ##STR1## which are useful as ligands of cholinergic receptors, in particular, receptors of the M.sub.1 type.
Claims12
A compound of the formula ##STR169## in which Ar" is a phenyl group of the formula ##STR170## R.sub.1b is hydrogen, a halogen atom, a hydroxyl group, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy or the trifluoromethyl group;
- R.sub.2b is hydrogen;
- R.sub.3b is a group --CH.sub.2 --C.sub.6 H.sub.5 or a group --CH.sub.2 --CH.sub.2 --C.sub.6 H.sub.5 ;
- and
- R.sub.4b is the group ##STR171## in which X is a linear or branched C.sub.1 -C.sub.6 alkylene and
- R.sub.5b and R.sub.6b are each independently hydrogen or a linear or branched C.sub.1 -C.sub.4 alkyl;
- or its salts which are pharmaceutically acceptable or permit crystallization thereof.
A 3-(2-diethylamino-2-methylprop-2-yl)amino-6-i-butyl-5-phenylpyridazine, or its salts which are pharmaceutically acceptable or permit crystallization thereof.
A 3-(2-diethylamino-2-methylprop-2-yl)amino-6-benzyl-5-phenylpyridazine, or its salts which are pharmaceutically acceptable or permit crystallization thereof.
A compound of formula (IB) ##STR173## in which:
- Ar" is a phenyl group of formula ##STR174## R.sub.1b is hydrogen, a halogen atom, a hydroxyl group, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group or a trifluoromethyl group;
- R.sub.2b is hydrogen;
- R.sub.3b is a linear or branched C.sub.1 -C.sub.5 alkyl group;
- and
- R.sub.4b is a group ##STR175## in which X is a linear or branched C.sub.1 -C.sub.6 alkylene and
- R.sub.5b and R.sub.6b are each independently hydrogen or a linear or branched C.sub.1 -C.sub.4 alkyl;
- or its salts which are pharmaceutically acceptable or permit crystallization thereof.
Dependencies are inferred from the claim text.