Collagen-based viscoelastic solution for visco-surgery

A collagen-based viscoelastic solution comprising acylated soluble collagen and a growth factor dissolved in a saline physiologic diluent, said growth factor having a concentration ranging from 10 ng/ml to 10,000 ng/ml, and said diluent having an ionic strength of no more than 0.001.mu. and said solution having an osmolarity ranging from 200 m osmol to 400 m osmol, wherein about 75 to about 95% of the osmolarity of said solution is provided by nonionic solutes.

A method of treating a patient comprising injection of a viscoelastic composition comprising an acylated soluble collagen in a saline physiologic buffer to separate and protect tissues being treated, said saline physiologic buffer having an ionic strength of no more than 0.001.mu. and said solution having an osmolarity ranging from 200 m osmol to 400 m osmol, wherein about 75 to about 95% of the osmolarity of said solution is provided by nonionic solutes.

A method of inserting an intraocular lens into the posterior or anterior chamber of a human or animal eye comprising:

• introducing into said anterior or posterior chamber an effective amount of a viscoelastic solution comprising acylated soluble collagen and a saline physiologic diluent having an ionic strength of no more than 0,001.mu. and said solution having an osmolarity ranging from 200 m osmol to 400 m osmol, wherein about 75 to about 95% of the osmolarity Of said solution is provided by nonionic solutes,
• said amount sufficient to reduce the trauma which normally results from inserting an intraocular lens into said chamber in the absence of a viscoelastic solution, and inserting said lens into said chamber.

A process of preparing a viscoelastic solution consisting essentially of reconstituting acylated soluble collagen in a saline physiologic diluent having an ionic strength of no more than 0.001.mu., said solution having an osmolarity ranging from 200 m osmol to 400 m osmol, wherein about 75 to about 95% of the osmolarity of said solution is provided by nonionic solutes.

A viscoelastic solution consisting essentially of acylated soluble collagen and a mucopolysaccharide in a saline physiologic diluent having an ionic strength of no more than 0.001.mu. and said solution having an osmolarity ranging from 200 m osmol to 400 m osmol, and a kinetic viscosity from 45,000 cps to 80,000 cps wherein bout 75 to about 95% of the osmolarity of said solution is provided by nonionic solutes.

A viscoelastic solution consisting essentially of acylated soluble collagen in a saline physiologic diluent having an ionic strength of no more than 0,001.mu. and said solution having an osmolarity ranging from 200 m osmol to 400 m osmol, and a kinetic viscosity ranging from 45,000 cps to 80,000 cps, wherein bout 75 to about 95% of the osmolarity of aid solution is provided by nonionic solutes.

A method of treating a patient with visco-surgery comprising injection of a viscoelastic composition of soluble collagen in a saline physiologic buffer to separate and protect tissues being treated, said saline physiologic buffer having an ionic strength of no more than 0.001.mu. and said solution having an osmolarity ranging from 200 m osmol to 400 m osmol, wherein about 75 to about 95% of the osmolarity of said solution is provided by nonionic solutes.