Anti-fungal and anti-bacterial histatin-based peptides
AssigneesPeriodontix, Inc., Trustees of Boston University
InventorsFrank G. Oppenheim, Tao Xu, F. Donald Roberts
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Abstract
Histatin-based peptides representing defined portions of the amino acid sequences of naturally occurring human histatins and methods for treatment of fungal or bacterial infection are described. These histatin-based peptides represent the active anti-fungal and anti-bacterial region of naturally occurring human histatins.
Claims8
A composition for treating a fungal or bacterial infection comprising a substantially pure peptide having an amino acid sequence, of at least 8 amino acids, selected from the amino acid sequence of peptide 113 as set forth in SEQ ID NO:
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Substantially pure peptide having an amino acid sequence, of at least nine amino acids, selected from the amino acid sequence of peptide 113 as set forth in SEQ ID NO:
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A method for treating a fungal or bacterial infection in an individual comprising administering to said individual a therapeutically effective amount of at least one peptide having an amino acid sequence, of at least 8 amino acids, selected from the amino acid sequence of peptide 113 as set forth in SEQ ID NO:
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Dependencies are inferred from the claim text.