Somatotropin analogs
AssigneeThe Upjohn Company
InventorsGary C. Harbour, John G. Hoogerheide, Robert L. Garlick, Stephen B. Lyle, John E. Mott
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Abstract
The present invention provides analogs of somatotropins wherein the asparagine residue corresponding to position 99 of a bovine somatotropin is replaced with a compound selected from the group consisting of proline, aspartic acid, glutamic acid, serine, glycine, serine-serine or serine-aspartic acid. Particularly preferred analogs are bovine somatotropin and their use to increase milk production.
Claims11
A non-naturally occurring mammalian somatotropin in which the amino acid corresponding to asparagine at position 99 of a native somatotropin is replaced with a different amino acid selected from the group consisting of aspartic acid and glutamic acid.
Dependencies are inferred from the claim text.