Pharmaceutical formulation
AssigneeNovo Nordisk A/S
InventorHans H. S.o slashed.rensen
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Abstract
A pharmaceutical formulation comprising a growth hormone and isoleucine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.
Claims12
A pharmaceutical formula comprising a growth hormone in the amount of about 0.1 mg/ml to about 40 mg/ml and isoleucine at a concentration up to about 100 mM.
A method of stabilizing a formulation of growth hormone in the amount of about 0.1 mg/ml to about 40 mg/ml, comprising adding leucine to the formulation in an amount up to about 100 mM.
Dependencies are inferred from the claim text.