Method of stimulating hematopoiesis with hemoglobin
AssigneeSomatogen, Inc.
InventorsGary J. Rosenthal, Michael J. Gerber
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Abstract
The present invention relates to a method for stimulating hematopoiesis in a mammal comprising administration of a therapeutically effective amount of a hemoglobin, including recombinant hemoglobin, and methods for treating cytopenias. These cytopenias include anemia, thrombocytopenia, lymphopenia, neutropenia and the like. The stimulation of hematopoiesis can occur both in vivo and ex vivo, as in the treatment of cytopenias associated with disease states, in cell culture or ex vivo expansion of bone marrow cells.
Claims24
A method for stimulating hematopoiesis in a mammal comprising administering to the mammal a therapeutically effective amount of purified hemoglobin.
A method for alleviating cytopenia in a mammal comprising administration to the mammal of a cytopenia alleviating effective amount of purified hemoglobin.
A method for enhancing growth or differentiation of mammalian progenitor stem cells comprising administration to a purified culture of a mammalian stem cell population of a stem cell stimulatory effective amount of hemoglobin.
Dependencies are inferred from the claim text.