Compositions comprising bone morphogenetic protein-2 (BMP-2)
AssigneeGenetics Institute, Inc.
InventorsElizabeth A. Wang, John M. Wozney, Vicki A. Rosen
Life of this patent
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Abstract
Purified BMP-2 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
Claims12
A composition comprising a purified protein produced by the steps of
- (a) culturing in a suitable culture medium a cell transformed with a DNA sequence comprising nucleotides #356 to #1543 as shown in FIG. 2;
- and
- (b) recovering and purifying the maulting secreted protein from said culture medium.
A composition comprising a purified protein produced by the steps of
- (a) culturing in a suitable culture medium a cell transformed with a DNA sequence comprising nucleotides #1 to #1543 as shown in FIG. 2;
- and
- (b) recovering and purifying from said culture medium a protein comprising amino acids #283-#396 of FIG. 2.
A composition comprising a purified protein produced by the steps of
- (a) culturine in a suitable culture medium a cell transformed with a DNA sequence comprising nucleotides #1202 to #1543 as shown in FIG. 2;
- and
- (b) recovering and purifying from said culture medium a protein comprising amino acids #283 to #396 of FIG. 2.
A composition comprising a purified protein produced by the steps of
- (a) culturine in a suitable culture medium a cell transformed with a DNA sequence comprising #356 to #1543 as shown in FIG. 2;
- and
- (b) recovering and purifying from said culture medium a protein comprising amino acids #283 to 396 of FIG. 2.
A composition comprising a purified protein characterized by amino acids #283 to #396 of FIG. 2.
A composition comprising a purified protein encoded by the DNA sequence of FIG. 2.
Dependencies are inferred from the claim text.