Aqueous antacids with calcium carbonate and magnesium salt
AssigneeMcNeil-PPC, Inc.
InventorsDouglas S. Beyerle, Gerard P. McNally
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Abstract
The present invention relates to an aqueous pharmaceutical suspension for oral use, and a method of preparation, having antacid and antiulcer properties which contains a therapeutically effective amount of calcium carbonate in combination with magnesium carbonate and/or magnesium trisilicate and a carboxylic acid pH adjusting agent.
Claims14
A stable aqueous antacid suspension for oral use having a pH of about 7.5 to about 8.5 of calcium carbonate in combination with a magnesium salt selected from the group consisting of magnesium carbonate, magnesium trisilicate and a mixture thereof as the sole active antacid component, prepared by a process which comprises in the order specified the steps of:
- (a) adding to water an effective antacid amount of particulate calcium carbonate and said magnesium salt, each in the particulate form of a micronized powder with 100% particle size distribution of about 0.1 to about 20 microns with mixing until the particulate material is completely wetted and dispersed;
- (b) adding to said dispersion with stirring an effective suspending amount of a thickening agent for a time sufficient to substantially coat said particulate material and to produce a suspension;
- and
- (c) adding to said suspension with stirring an effective pH adjusting amount of a carboxylic acid pH adjusting agent to provide a pH of about 7.5 to about 8.5 to the aqueous antacid suspension.
A stable aqueous antacid suspension for oral use with pH of about 8.0 to about 8.3 of calcium carbonate and magnesium carbonate as the sole active antacid component, prepared by a process which comprises in the order specified the steps of:
- (a) adding to water an effective antacid amount of particulate calcium carbonate and particulate magnesium carbonate, each in the form of a micronized powder with 100% particle size distribution of about 0.1 to about 20 microns with mixing until the particulate material is completely wetted and dispersed;
- (b) adding to said dispersion an effective suspending amount of xanthan gum or xanthan gum premixed with glycerin, with stirring for a time sufficient to substantially coat said particulate material and to provide a suspension;
- and
- (c) adding to said suspension with stirring an effective pH adjusting amount of tartaric acid to provide a pH of about 8.0 to about 8.3 to the final antacid suspension.
Dependencies are inferred from the claim text.