Phosphorylated polyazamacrocyclic compounds for complexation of metal ions
AssigneesBoard of Regents, The University of Texas System, The Dow Chemical Company
InventorsA. Dean Sherry, Garry E. Kiefer
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Abstract
The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses as a tissue specific chelator. The compound has the formula ##STR1## where x is 2, 3 or a combination of p 2(s) and q 3(s) where p +q=y; y is 3 or 4; R is (CH.sub.2).sub.z P(.dbd.O)OR.sup.1 OR.sup.2 ; R.sup.1 is H or CH.sub.3 ; R.sup.2 is C.sub.n H.sub.1+2n ; n is 4 to 6; z is 1 to 3. In one important embodiment, this compound may be complexed with a metal to be a polyazamacrocyclic compound-metal complex having the formula ##STR2## where r is 2 or 3; and M is a metal ion, including a lanthanide, a heavy metal, or a radionuclide metal.
Claims27
A polyazamacrocyclic compound or a salt thereof, the compound having the formula ##STR6## where x is 2, 3 or a combination of p 2(s) and q 3(s) where p+q=y;
- y is 3 or4;
- R is (CH.sub.2).sub.z P(.dbd.O)OR.sup.1 OR.sup.2 ;
- R.sup.1 is H or CH.sub.3 ;
- R.sup.2 is C.sub.n H.sub.1+2n ;
- z is 1 to 3;
- and
- n is 4 to 6.
A polyazamacrocyclic compound-metal complex having the formula ##STR7## where x is 2, 3 or a combination of p 2(s) and q 3(s) where p+q=y;
- y is 3 or 4;
- R is (CH.sub.2).sub.z P(.dbd.O)OR.sup.1 OR.sup.2 ;
- R.sup.1 is H or CH.sub.3 ;
- R.sup.2 is C.sub.n H.sub.1+2n ;
- z is 1 to 3;
- r is 2 or 3;
- M is a metal ion;
- and
- n is 4 to 6.
A compound or salt thereof, the compound having the formula:
- ##STR8## where R is C.sub.n H.sub.1+2n ;
- n is 4 to 6;
- and
- R' is H.
A compound or salt thereof, the compound having the formula:
- ##STR9## where R.sup.1 is OC.sub.n H.sub.1+2n ;
- n is 4 to 6;
- and
- R.sup.2 is H.
A polyazamacrocyclic compound or a salt thereof, the compound having the formula ##STR10## where x is 2, 3 or a combination of p 2(s) and q 3(s) where p+q=Y;
- y is 3 or 4
- R is (CH.sub.2).sub.z P(.dbd.O)OR.sup.1 OR.sup.2 ;
- R.sup.1 is H;
- R.sup.2 is C.sub.4 H.sub.9 ;
- and
- z is 1 to 3.
A polyazamacrocyclic compound-metal complex having the formula ##STR11## where x is 2, 3 or a combination of p 2(s) and q 3 (s) where p+q=y;
- y is 3 or 4;
- R is (CH.sub.2).sub.z P(.dbd.O)OR.sup.1 OR.sup.2 ;
- R.sup.1 is H;
- R.sup.2 is C.sub.4 H.sub.9 ;
- z is 1 to 3;
- r is 2 or 3;
- and
- M is a metal ion.
A compound or salt thereof, the compound having the formula:
- ##STR12##
Dependencies are inferred from the claim text.