Preparation of biologically active molecules by molecular imprinting
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorAbraham J. Domb
Life of this patent
Estimating the term…
Abstract
A method for preparing mimics of a wide variety of drugs and other biologically active molecules using molecular imprinting techniques, and the mimics produced thereby, is disclosed. Specifically, the mimic is designed by: (i) polymerization of functional monomers around a known drug or biologically active molecule (the template) that exhibits a desired activity; (ii) removal of the template molecule; and then (iii) polymerization of a second class of monomers in the void left by the template, to provide a new organic molecule which exhibits one or more desired properties which are similar to that of the template.
Claims36
A method for preparing molecules comprising:
- (a) polymerization of functional monomers around a template molecule that exhibits a desired known biological activity;
- (b) removal of the template molecule;
- and
- (c) polymerization of a second class of monomers in the void left by the template.
Dependencies are inferred from the claim text.