Method of delivering powder transdermally with needless injector
AssigneeOxford Biosciences Limited
InventorsBrian J. Bellhouse, David F. Sarphie, John C. Greenford
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Abstract
A needleless syringe having a membrane which is ruptured by gas pressure to generate a supersonic gas flow in which particles containing a therapeutic agent are injected. This provides effective transdermal delivery of the therapeutic agent.
Claims14
A method of therapeutic treatment, comprising transdermally delivering particles of a powdered therapeutic agent across skin tissue of a mammalian subject, said particles being delivered to the locus of transdermal administration at a velocity in the range of between 200 and 2,500 m/sec, in which the particles of the therapeutic agent have a size predominantly in the range of about 10 to 250 .mu.m and a density in the range of 0.1 to 25 g/cm.sup.3.
A method of therapeutic treatment, comprising transdermally delivering particles of a powdered therapeutic agent across skin tissue of a mammalian subject, wherein said particles have a size predominantly in the range of about 10 to 250 .mu.m and are delivered to the locus of transdermal administration at a momentum density of between 2 and 10 kg/sec/m.
A method of therapeutic treatment, comprising transdermally delivering particles of a powdered therapeutic agent combined with an inert carrier or diluent across skin tissue of a mammalian subject, said particles being delivered to the locus of transdermal administration at a velocity in the range of between 200 and 2,500 m/sec, in which the particles of the therapeutic agent have a size predominantly in the range of about 10 to 250 .mu.m and a density in the range of 0.1 to 25 g/cm.sup.3.
A method of therapeutic treatment, comprising transdermally delivering particles of a powdered therapeutic agent combined with an inert carrier or diluent across skin tissue of a mammalian subject, wherein said particles have a size predominantly in the range of about 10 to 250 .mu.m and are delivered to the locus of transdermal administration at a momentum density of between 2 and 10 kg/sec/m.
Dependencies are inferred from the claim text.