US 5,629,454 AGranted

Conformationally locked nucleoside analogues

AssigneeThe United States of America as represented by the Department of Health and Human Services

InventorsVictor E. Marquez, Juan B. Rodriguez, Marc C. Nicklaus, Joseph J. Barchi, Jr., Maqbool A. Siddiqui

Life of this patent

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Abstract

Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.

Claims12

Dependent claims

A compound having the formula ##STR7## wherein R is selected from the group consisting of alkyl, aryl, alkylaryl and aroyl.

Dependencies are inferred from the claim text.

Facts

Application: 08/311,425Filed 23 Sep 1994 · continuation in part
Priority: 24 Sep 1993
Granted: 13 May 1997
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07D 239/47
Two or more oxygen, sulphur or nitrogen atoms: one nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
A61P 31/18
For RNA viruses: for HIV
C07D 239/54
Two oxygen atoms: as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
C07D 473/18
With oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6: one oxygen and one nitrogen atom, e.g. guanine

Family

Serial126,796Parent of this continuation-in-part · filed 24 Sep 1993
US 5,629,454 AThis patent

From the US filing history. Foreign family members aren’t listed.

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