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US 5,629,450 AGranted
Addition salt of acyl-amino acid and .alpha.-aryl amine and process for optical resolution of .alpha.-arylamine
AssigneeAjinomoto Co., Inc.
InventorsToyoto Hijiya, Teruo Yonekawa, Tadashi Takemoto
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Abstract
To produce optically active .alpha.-arylalkylamine from optically impure .alpha.-arylalkylamine. Optically impure .alpha.-arylalkylamine is mixed with optically active N-acyl-aspartic acid or glutamic acid in a solvent and the resulting two types of diastereomer salts are optically resolved utilizing difference in solubility.
Claims2
A process for optical resolution, comprising:
- i) mixing an optically active N-acyl-aspartic acid or an optically active N-acyl-glutamic acid and an optically impure .alpha.-arylalkylamine in a solvent to form the corresponding diastereomeric salts;
- and
- ii) separating the two diastereomeric salts utilizing differences in solubility,
- wherein the aryl in said .alpha.-arylalkylamine is selected from the group consisting of phenyl, C.sub.1-6 alkyl-substituted phenyl and naphthyl, and wherein the acyl group of said N-acyl-aspartic acid or N-acyl-glutamic acid is selected from the group consisting of benzyloxycarbonyl, benzoyl, benzenesulfonyl or p-toluenesulfonyl.
1 more element
Dependencies are inferred from the claim text.