Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thi ophene
AssigneeEli Lilly and Company
InventorsElizabeth S. LaBell, John M. McGill, Randal S. Miller
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Abstract
The present invention is directed to chemical processes for preparing 2-aryl-6-hydroxy-3-[4-(2-aminoethoxy)benzoyl]benzo[b]thiophenes. The present invention is also directed to crystalline solvates and a non-solvated crystalline form of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thi ophene hydrochloride, as well as processes for their preparation.
Claims5
The compound being the 1,2-dichloroethane hemisolvate of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(piperidinoethoxy)benzoyl]benzo[b]thiop hene hydrochloride.
The compound being the 1,2,3-trichloropropane hemisolvate of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(piperidinoethoxy)benzoyl]benzo[b]thiop hene hydrochloride.
Dependencies are inferred from the claim text.