Boswellic acid compositions and preparation thereof
AssigneeCouncil of Scientific and Industrial Research
InventorsSubhash C. Taneja, Vijay K. Sethi, Kanaya L. Dhar, Randhir S. Kapil
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Abstract
Disclosed herein is a novel fraction comprising a mixture of boswellic acids, wherein the fraction exhibits anti-inflammatory and antiulcerogenic activities. Also disclosed is a novel boswellic acid compound exhibiting anti-inflammatory, antiathritic and antiulcerogenic activities. Also disclosed is a process for isolating a boswellic acid fraction and individual boswellic acids therefrom.
Claims9
A novel composition exhibiting anti-inflammatory and antiulcerogenic activities, said composition comprising a mixture of boswellic acids of the formulae I through VI identified as follows:
- ##STR3## said composition comprising 35% to 55% by weight of a compound of Formula I, 25% to 45% by weight of a compound of Formula II, 4% to 14% by weight of a compound of Formula III, 3% to 13% by weight of a compound of Formula IV, 1% to 3% by weight of a compound of Formula V, and 1% to 3% by weight of a compound of Formula VI.
A boswellic acid compound exhibiting anti-inflammatory antiathritic and antiulcerogenic activities and having the structural formula:
- ##STR4## said compound being produced by separating said compound from a composition comprising:
- ##STR5## said composition comprising 35% to 55% by weight of a compound of Formula I, 25% to 45% by weight of a compound of Formula II, 4% to 14% by weight of a compound of Formula III, 3% to 13% by weight of compound of Formula IV, 1% to 3% by weight of a compound of Formula V, and 1% to 3% by weight of a compound of Formula VI.
A process for the isolation of a boswellic acid fraction exhibiting anti-inflammatory and antiulcerogenic activities, said fraction comprising a mixture of boswellic acids, and optionally isolating individual boswellic acids from said fraction, said process comprising the steps of:
- (a) crushing the lumps of the gum resin of Boswellia serrata and extracting the crushed lumps with a polar solvent to provide an extract;
- (b) filtering or centrifuging said extract to remove insoluble material from said extract;
- (c) vacuum distilling the extract untill a reddish brown syrupy mass is obtained;
- (d) basifying the syrupy mass with an aqueous solution of an alkali to provide a solution having a pH in the range of 9 to 10;
- (e) extracting the solution with chlorinated or non-polar solvents to provide an aqueous layer, and acidifying the aqueous layer with mineral acid to a pH in the range of 3-5 to provide a precipitate comprising boswellic acids;
- (f) washing the precipitate with water to provide said fraction being neutral to litmus;
- (g) drying the fraction to provide a dry fraction,
- said dry fraction comprises:
- (a) 35 to 55% by weight of a compound of the formula:
- ##STR6## (b) 25 to 45% by weight of a compound of the formula:
- ##STR7## (c) 4 to 14% by weight of a compound of the formula:
- ##STR8## (d) 3 to 13% by weight of a compound of the formula:
- ##STR9## (e) 1 to 3% of a compound of the formula:
- ##STR10## and, (f) 1 to 3% by weight of a compound of the formula:
- ##STR11##
Dependencies are inferred from the claim text.