Angiogenesis inhibitor and novel compound
AssigneeTsumura & Co.
InventorsMichihiko Kuwano, Mayumi Ono, Mika Kusano, Junko Watanabe, Masakazu Takeda
Life of this patent
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Abstract
An angiogenesis inhibitor comprising, as an active agent, Compound (I) represented by the formula below: ##STR1## where R.sub.1 is a lower alkyl group, an alkoxycarbonyl group or a carboxyl group; and R.sub.2, R.sub.3 and R.sub.4 maybe the same or different and represent a hydrogen atom, a hydroxyl group, a methoxy group or an acetoxy group. This compound has a remarkable angiogenesis inhibition activity, and an angiogenesis inhibitor useful for treatment of various diseases are provided.
Claims4
An angiogenesis inhibitor comprising, as an active ingredient, a mixture of
- Compound I represented by general formula (I) below:
- ##STR9## where R.sub.1 is a lower alkyl group having 1 to 4 carbon atoms, an alkoxycarbonyl group having 1 to 4 carbon atoms in the alkoxy moiety or a carboxyl group;
- and
- R.sub.2, R.sub.3 and R.sub.4 may be the same or different and each represents a hydrogen atom, a hydroxyl group, a methoxy group or an acetoxy group, wherein R.sub.2 and R.sub.3 may bind together to close a ring, as shown in general formula (II) below:
- --O--(CH.sub.2).sub.m --O-- (II)
- where m is an integer from 1 to 6;
- Compound III represented by general formula (III) below:
- ##STR10## where R.sub.5 is a lower alkyl group having 1 to 4 carbon atoms;
- and R.sub.6, R.sub.7 and R.sub.8 may be the same or different and each represents a hydrogen atom, a hydroxyl group, a methoxy group or an acetoxy group;
- and
- Compound IV represented by general formula (IV) below:
- ##STR11## where R.sub.10 and R.sub.11 may be the same or different and each represents a lower alkyl group having to 4 carbon atoms;
- and R.sub.12 and R.sub.13 may be the same or different and each represents a hydroxyl group or a methoxy group.
An angiogenesis inhibitor comprising, as an active ingredient, compound I represented by general formula (I) below:
- ##STR12## where R.sub.1 represents a lower alkyl group having 1 to 4 carbon atoms, an alkoxycarbonyl group having 1 to 4 carbon atoms in the alkoxy moiety or a carboxyl group;
- R.sub.2, R.sub.3 and R.sub.4 may be the same or different and each represents a hydrogen atom, a hydroxyl group, a methoxy group or an acetoxy group and wherein R.sub.2 and R.sub.3 may bind together to close a ring as shown in general formula (II) below:
- --O--(CH.sub.2)m--O-- (II)
- where m is an integer from 1 to 6.
An angiogenesis inhibitor comprising, as an active ingredient, compound III represented by the general formula (III) below:
- ##STR13## where R.sub.5 is a lower alkyl group having 1 to 4 carbon atoms;
- and R.sub.6, R.sub.7 and R.sub.8 may be the same or different and each represents a hydrogen atom, a hydroxyl group, a methoxy group or an acetoxy group.
An angiogenesis inhibitor comprising, as an active ingredient, a compound IV represented by general formula (IV) below:
- ##STR14## where, R.sub.10 and R.sub.11 may be the same or different and each represents a lower alkyl group having 1 to 4 carbon atoms;
- and R.sub.12 and R.sub.13 may be the same or different and each represents a hydroxyl group or a methoxy group.
Dependencies are inferred from the claim text.