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US 5,629,323 AGranted
Amide derivatives as 5-HT.sub.1A ligands
AssigneeJohn Wyeth & Brother Limited
InventorsIan A. Cliffe, Anderson D. Ifill
Life of this patent
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Abstract
Amide Derivatives of formula (I) wherein R.sup.1 is a mono or bicyclic heteroaryl radical, R.sup.2 is cycloalkyl, R.sup.3 and R.sup.4 each represent hydrogen or lower alkyl, and R.sup.5 is a group of formula (A) or (B) or (C): R.sup.8 --CH.sub.2 --CH.sub.2 -- or (D) or (E): R.sup.9 OCH.sub.2 CHOHCH.sub.2 -- or (F): R.sup.9 OCH.sub.2 CH.sub.2 -- and their pharmaceutically acceptable salts are 5-HT.sub.1A binding agents and may be used, for example, as anxiolytics. ##STR1##
Claims18
A compound of the general formula ##STR15## or a pharmaceutically acceptable salt thereof wherein
- R.sup.1 is pyridinyl,
- R.sup.2 is C.sub.3 -C.sub.8 cycloalkyl,
- R.sup.3,R.sup.3' and R.sup.4 each represent hydrogen or C.sub.1 -C.sub.6 alkyl,
- R.sup.5 is ##STR16## R.sup.6 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, hydroxy, halogen trifluoromethyl, C.sub.1 -C.sub.6 alkoxycarbonyl, carboxamido, nitro, cyano, amino, C.sub.1 -C.sub.6 alkylamino, di-C.sub.1 -C.sub.6 alkylamino or C.sub.1 -C.sub.6 alkylcarbonyl.
1 more element
Dependencies are inferred from the claim text.