Bicyclic compound and platelet aggregation inhibitor containing the same
AssigneeMitsui Toatsu Chemicals, Inc.
InventorsKunio Okumura, Isao Yokoyama, Toshiyuki Shimazaki, Michihiko Miyamoto, Hiroyuki Yamashita, Kenji Kibayashi, Takanori Yutaka, Kouhei Yazawa
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Abstract
The invention relates to a novel compound which is represented by the formula (1) and has an excellent platelet aggregation inhibiting action based on fibrinogen antagonism. The platelet aggregation inhibitor containing the compound of the formula (1) as an effective ingredient are effective for prevention and curing of thrombosis and restenosis or reocclusion after percutaneous transluminal coronary angioplasty or percutaneous transluminal coronary recanalization.
Claims27
A compound or a pharmaceutically acceptable salt thereof represented by the formula (1):
- ##STR30## wherein A is an amidino group, guanidino group or aminomethyl group, B is -CH.sub.2 O-, -OCH.sub.2 -, -CH.sub.2 N(R.sup.1)-, -N(R.sup.1)CH.sub.2 -, -CON(R.sup.1)- or -N(R.sup.1) CO-, wherein R.sup.1 is a hydrogen atom or an alkyl group having 1-4 carbon atoms:
- W-X [-CH.sub.2 -CH.dbd., -CH.sub.2 -N.dbd. or -CH.dbd.C.dbd.] ##STR31## Y is -CH.sub.2 - or -O-, with the proviso that when W-X is ##STR32## Y is not -O-;
- and Z is a hydrogen atom or an alkyl group having 1-4 carbon atoms.
7-[(4-amidinobenzoyl)amino]-1,2,3,4-tetrahydronaphthalene-2-acetic acid, 7-[N-(4-amidinophenyl)carbamoyl]-1,2,3,4-tetrahydronaphthalene-2-acetic acid, 6-[(4-amidinobenzoyl) amino]chroman-3-acetic acid, 7-[(4-amidinobenzoyl)amino]-1,2,3,4-tetrahydroisoquinoline-2-acetic acid or a pharmaceutically acceptable salt thereof.
A compound or a pharmaceutically acceptable salt thereof represented by the formula (2):
- ##STR34## wherein G is a cyano group or HN.dbd.C(OR.sup.2)-, wherein R.sup.2 is an alkyl group having 1-4 carbon atoms;
- B is -CH.sub.2 O-, -OCH.sub.2 -, -CH.sub.2 N(R.sup.1)-, -N(R.sup.1)CH.sub.2 -, -CON(R.sup.1)- or -N(R.sup.1)CO-, wherein R.sup.1 is a hydrogen atom or an alkyl group having 1-4 carbon atoms;
- W-X is [-CH.sub.2 -CH.dbd., -CH.sub.2 -N.dbd. or -CH.dbd.C] ##STR35## Y is -CH.sub.2 - or -O-, with the proviso that when W-X is ##STR36## Y is not -O-;
- and Z is a hydrogen atom or an alkyl group having 1-4 carbon atoms.
Dependencies are inferred from the claim text.