Tetrahydro-beta-carbolines

A compound of the Formula I ##STR13## wherein Q is R.sub.34 ;

• R.sub.34 is spirobicyclic, substituted spirobicyclic, bicyclic or substituted bicyclic having an unsaturated or saturated stable 7 to 12 member bridged or fused bicyclic carbon ring system;
• R.sub.1 is hydrogen or C.sub.1 -C.sub.3 alkyl;
• R.sub.2 is hydrogen or C.sub.1 -C.sub.6 alkyl;
• R.sub.3 is hydrogen or C.sub.1 -C.sub.3 alkyl;
• R.sub.4 is C.sub.5 -C.sub.8 cycloalkyl, substituted C.sub.5 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.8 cycloalkenyl, substituted C.sub.5 -C.sub.8 cycloalkenyl, bicyclic or substituted bicyclic;
• A is selected from the group consisting of ##STR14## wherein R.sub.6 and R.sub.7 are, independently, hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, halo, halo(C.sub.1 -C.sub.6)alkyl, halo(C.sub.2 -C.sub.6)alkenyl, COR.sub.5, C.sub.1 -C.sub.10 alkanoyl, CO.sub.2 R.sub.5', (C.sub.1 -C.sub.6 alkyl).sub.m amino, NO.sub.2, --SR.sub.5, or OR.sub.5 ;
• m is 1 or 2;
• R.sub.5 is independently hydrogen or C.sub.1 -C.sub.4 alkyl;
• R.sub.5' is C.sub.1 -C.sub.4 alkyl;
• R.sub.8 is independently selected from the group consisting of an R.sub.6 group, substituted C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkyl-(C.sub.1 -C.sub.3)alkyl, C.sub.5 -C.sub.8 cycloalkenyl, substituted C.sub.5 -C.sub.8 cycloalkenyl, C.sub.5 -C.sub.8 cycloalkenyl-(C.sub.1 -C.sub.3)alkyl, C.sub.7 -C.sub.16 arylalkyl;
• or
• R.sub.6 and R.sub.7 together with the carbon atoms of group A form a 5- to 8-member carbon ring;
• R.sup.30 and R.sup.31 join to form a 3 to 8 member carbon ring;
• or
• R.sup.30 and R.sup.31 are independently selected from the group consisting of C.sub.1 -C.sub.6 alkyl and C.sub.2 -C.sub.6 alkenyl;
• substituted cycloalkyl is substituted with from one to four substituents independently selected from the group consisting of C.sub.1 -C.sub.6 alkyl, NO.sub.2, halo, halo(C.sub.1 -C.sub.6)alkyl, halo(C.sub.2 -C.sub.6)alkenyl, C.sub.2 -C.sub.6 alkenyl, CO.sub.2 R.sub.5, (C.sub.1 -C.sub.6 alkyl).sub.m amino, --SR.sub.5, and OR.sub.5 or;
• substituted cycloalkyl, substituted spirobicyclic and substituted bicyclic are each independently substituted with from one to four substituents independently selected from the group consisting of C.sub.1 -C.sub.6 alkyl, NO.sub.2, halo, halo(C.sub.1 -C.sub.6)alkyl, halo(C.sub.2 -C.sub.6)alkenyl, C.sub.2 -C.sub.6 alkenyl, COR.sub.5, C.sub.1 -C.sub.10 alkanoyl, C.sub.7 -C.sub.16 arylalkyl, CO.sub.2 R.sub.5, (C.sub.1 -C.sub.6 alkyl).sub.m amino, --SR.sub.5, and OR.sub.5 ;
• wherein R.sub.5 is independently hydrogen or C.sub.1 -C.sub.4 alkyl;
• bicyclic is selected from the group consisting of naphthyl, dicyclohexyl and dicyclohexenyl;
• spirobicyclic is selected from the group consisting of naphthyl, dicyclohexyl, dicyclonhexenyl, 1,2,3,4-tetrahydronaphthol and ##STR15## a pharmaceutically acceptable salt or solvate thereof.