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AssigneeTakeda Chemical Industries, Ltd.
InventorsMasahiko Kurihara, Shunichi Itoh, Kou Moriyama, Mitsutaka Isobe, Kenichiro Kiyoshima
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To stabilize the active ingredients, a caffeine is incorporated into a solid pharmaceutical preparation comprising a dextromethorphan and a phenylpropanolamine. The pharmaceutical preparation may further comprise ibuprofen. The active ingredients may be further stabilized, in combination with the incorporation of the caffeine, by grouping and incorporating separately each or suitably combined plural of the active ingredients into different groups or by minimizing the amount of any reducing sugar such as lactose. The solid pharmaceutical preparation is practically valuable since decomposition of each active ingredient with the lapse of time is remarkably suppressed and the active ingredients are stabilized for a longer period of time.
A stabilized solid pharmaceutical preparation which comprises a dextromethorphan and a phenylpropanolamine as active ingredients and a caffeine as stabilizer, the content of the caffeine being 10 to 300 parts by weight relative to 100 parts by weight of each of said active ingredients.
A stabilizing method which comprises incorporating a stabilizing effective amount of a caffeine into a solid pharmaceutical preparation containing a dextromethorphan and a phenylpropanolamine as active ingredients, the amount of caffeine being 7 to 500 parts by weight relative to 100 parts by weight of the total weight of active ingredients.
A method of producing a stabilized solid pharmaceutical preparation which comprises incorporating a stabilizing effective amount of a caffeine into a solid pharmaceutical preparation comprising a dextromethorphan and a phenylpropanolamine, the content of the caffeine being 10 to 300 parts by weight relative to 100 parts by weight of each of said active ingredients.
A stabilized solid pharmaceutical preparation which comprises a dextromethorphan and a phenylpropanolamine as active ingredients and a caffeine as stabilizer, wherein said preparation is composed of granules comprising the dextromethorphan, the phenylpropanolamine and the caffeine, and the content of the caffeine is 10 to 300 parts by weight relative to 100 parts by weight of each of said active ingredients.
Dependencies are inferred from the claim text.