Substituted cyclohexanol esters their use for treating diseases and pharmaceutical preparations

A cyclohexanol ester of the formula I:

• ##STR23## in which R.sup.1 is ##STR24## in which aromatic rings may be substituted at least once by F, Cl, Br, I, OH, O--C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkyl, CF.sub.3, NO.sub.2 or CN,
• R.sup.2 is C.sub.1 -C.sub.10 -alkyl(R.sup.11).sub.n, O--C.sub.1 -C.sub.10 -alkyl(R.sup.11).sub.n, C.sub.2 -C.sub.10 -alkenyl (R.sup.11).sub.n, O--C.sub.3 -C.sub.10 -alkenyl (R.sup.11).sub.n, C.sub.2 -C.sub.10 -alkynyl (R.sup.11).sub.n, O--C.sub.3 -C.sub.10 -alkynyl (R.sup.11).sub.n, S--C.sub.1 -C.sub.10 -alkyl (R.sup.11).sub.n, S--C.sub.3 -C.sub.10 -alkenyl (R.sup.11).sub.n, S--C.sub.3 -C.sub.10 -alkynyl (R.sup.11).sub.n, NH--C.sub.3 -C.sub.10 -alkyl (R.sup.11).sub.n, NH--C.sub.3 -C.sub.10 -alkenyl (R.sup.11).sub.n or NH--C.sub.3 -C.sub.10 -alkynyl (R.sup.11).sub.n, where R.sup.11 is optionally substituted by R.sup.12,
• R.sup.3, R.sup.11 and R.sup.13 are alkyl having from 1 to 10 carbon atoms, cycloalkyl having from 3 to 8 ring carbon atoms, phenyl, naphthyl, phenanthryl, pyridyl, thienyl, furyl, pyrimidyl, indolyl, imidazolyl, coumadnyl, phthaliminyl, quinolyl, piperazinyl, -tetrazolyl, triazolyl, oxazolyl or their thieno-fused, pyridino-fused, pyrimidino-fused or benzo-fused derivatives, where the aromatic radical or heteroaromatic radical maybe substituted at least once, identically or differently, by F, Cl, Br, I, OH, --NO.sub.2, CN, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkyl, NR.sup.8 R.sup.9, phenyl, benzyl, thienyl, furyl, imidazolyl, pyridyl, O-phenyl or O-benzyl, and R.sup.3, R.sup.11 and R.sup.13 are identical or different;
• R.sup.4, R.sup.5 and R.sup.6 are H, OH, an OH group protected by customary alcohol protective groups, F, Cl or Br, or have the meanings given for R.sup.2, where R.sup.4, R.sup.5 and R.sup.6 are identical or different;
• R.sup.7 is C.sub.1 -C.sub.4 -alkyl, phenyl or benzyl;
• R.sup.8 and R.sup.9 are H, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkanoyl or phenyl which is optionally substituted by F, Cl, Br, I, OH, O--C.sub.1 -C.sub.4 -alkyl, CF.sub.3, --NO.sub.2 or CN, where R.sup.8 and R.sup.9 are identical or different, or R.sup.8 and R.sup.9 form, together with the nitrogen atom, a 4- to 10-membered, saturated heterocyclic ring in which a CH.sub.2 group may be optionally replaced by O, S or NR.sup.10 R.sup.10 is H, C.sub.1 -C.sub.4 -alkyl, phenyl or benzyl;
• R.sup.12 is phenyl, naphthyl, phenanthryl, pyridyl, thienyl, furyl, thiazolyl, pyrimidyl, indolyl, imidazolyl, coumarinyl, phthaliminyl, quinolyl, piperazinyl, tetrazolyl, triazolyl, oxazolyl or their thieno-fused or benzo-fused derivatives, where the aromatic radical or heteroaromatic radical may be substituted at least once, identically or differently, by F, Cl, Br, I, OH, CF.sub.3, --NO.sub.2, CN, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkyl, NR.sup.8 R.sup.9, phenyl, benzyl, thienyl, furyl, imidazolyl, pyridyl, O-phenyl or O-benzyl;
• X is (CH.sub.2).sub.m, --CH=CH--, --C.ident.C--, --CH.sub.2 --O--CH.sub.2 --, --CH.sub.2 --S--CH.sub.2 -- or ##STR25## Y is (CH.sub.2).sub.m, O, S or NR.sup.8, Z is (CH.sub.2).sub.m, S, O, S--C.sub.1 -C.sub.10 -alkyl, O--C.sub.1 -C.sub.10 -alkyl, CH=CH, CH=CF, CH=CCl, CH=CBr, CH.sub.2 --CO, CH.sub.2 --CHF, CH.sub.2 --CHCl, CH.sub.2 --CHBr, CH.sub.2 --CHl, C.sub.3 -C.sub.10 -cycloalkylene, C.sub.3 -C.sub.10 -cycloalkenylene, where from 1 to 3 ring carbon atoms may be replaced by sulfur atoms, oxygen atoms or nitrogen atoms, COOR.sup.7, C.ident.C, CH=C(C.sub.1 -C.sub.4 -alkyl), CH=C(CN), CH=C(NR.sup.8 R.sup.9), CH=C(C.sub.1 -C.sub.4 -alkanoyl), or CH=C(R.sup.13) or NR.sup.8, and, if Y is oxygen, ##STR26## may together be an amino acid residue, selected from the group consisting of Ala, Arg, Ash, Asp, Cys, Gin, Glu, Gly, His, Ile, Leu, Lys, Phe, Pro, Set, Thr, Trp, Tyr and their derivatives protected by customary protective groups,
• n is zero, 1 or 2,
• m is zero, 1, 2, 3 or 4, or a physiologically tolerated salt of a compound of the formula I.