Imidazo [1,2-A] (pyrrolo, thieno or furano) [2,3-D] azepine derivatives

A compound having the formula ##STR24## a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, wherein

• each of the dotted lines independently represents an optional bond;
• R.sup.1 represents hydrogen, C.sub.1-4 alkyl, halo, ethenyl substituted with hydroxycarbonyl or C.sub.1-4 alkyloxycarbonyl, hydroxyC.sub.1-4 alkyl, formyl, hydroxycarbonyl or hydroxycarbonylC.sub.1-4 alkyl;
• R.sup.2 represents hydrogen, C.sub.1-4 alkyl, ethenyl substituted with hydroxycarbonyl or C.sub.1-4 alkyloxycarbonyl, C.sub.1-4 alkyl substituted with hydroxycarbonyl or C.sub.1-4 alkyloxycarbonyl, hydroxyC.sub.1-4 alkyl, formyl or hydroxycarbonyl;
• R.sup.3 represents hydrogen, C.sub.1-4 alkyl, hydroxyC.sub.1-4 alkyl, phenyl or halo;
• X represents O, S or NR.sub.4 ;
• R.sup.4 represents hydrogen, C.sub.1-6 alkyl or C.sub.1-4 alkylcarbonyl;
• L represents hydrogen;
• C.sub.1-6 alkyl;
• C.sub.1-6 alkyl substituted with one substituent selected from the group consisting of hydroxy, C.sub.1-4 alkyloxy, hydroxycarbonyl, C.sub.1-4 alkyloxycarbonyl, C.sub.1-4 alkylaminocarbonyl, C.sub.1-4 alkyloxycarbonylamino, C.sub.1-4 alkyloxycarbonylC.sub.1-4 alkyloxy, hydroxycarbonylC.sub.1-4 alkyloxy, C.sub.1-4 alkylaminocarbonylamino, C.sub.1-4 alkylaminothiocarbonylamino, aryl and aryloxy;
• C.sub.1-6 alkyl substituted with both hydroxy and aryloxy;
• C.sub.3-6 alkenyl;
• C.sub.3-6 alkenyl substituted with aryl;
• wherein each aryl is phenyl or phenyl substituted with halo, cyano, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy or aminocarbonyl or,
• L represents a radical of formula
• --Alk-y-Het.sup.1 (a-1),
• --Alk-NH-CO-Het.sup.2 (a-2) or
• --Alk-Het.sup.3 (a-3);
• wherein
• Alk represents C.sub.1-4 alkanediyl;
• Y represents O, S or NH;
• Het.sup.1, Het.sup.2 and Her.sup.3 each represent furanyl, thienyl, oxazolyl, thiazolyl or imidazolyl each optionally substituted with one or two C.sub.1-4 alkyl substituents;
• pyrrolyl or pyrazolyl optionallly substituted with formyl, hydroxyC.sub.1-4 alkyl, hydroxycarbonyl, C.sub.1-4 alkyloxycarbonyl or with one or two C.sub.1-4 alkyl substituents;
• thiadiazolyl or oxadiazolyl optionally substituted with amino or C.sub.1-4 alkyl;
• pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl each optionally substituted with C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, amino, hydroxy or halo;
• and
• Het.sup.3 may also represent 4,5-dihydro-5-oxo-1H-tetrazolyl substituted with C.sub.1-4 alkyl, 2-oxo-3-oxazolidinyl, 2,3-dihydro-2-oxo-1H-benzimidazol-l-yl or a radical of formula ##STR25## A-Z represents S-CH.dbd.CH, S-CH.sub.2 -CH.sub.2, S-CH.sub.2 -CH.sub.2 -CH.sub.2, CH.dbd.CH-CH.dbd.CH, or CH.sub.2 -CH.sub.2 -CH.sub.2 -CH.sub.2.