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US 5,629,302 AGranted
Biotenside esters and phosphatides with vitamin-D and vitamin-E compounds; processes for their preparation; spontaneously dispersible agents containing these compounds, and their use for the treatment of tumors
AssigneeMarigen S.A.
InventorsCarl Eugster, Conrad Hans Eugster, Walter Haldemann, Giorgio Rivara
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Abstract
New biotenside esters and phosphatides formed with Vitamin-D and Vitamin-E compounds possessing a pronounced antitumor activity, processes for their production as well as for the preparation of concentrates and pharmaceutical compositions containing these new esters and phosphatides, and their use for treating tumors are described.
Claims11
A spontaneously dispersible concentrate which forms a microemulsion in water comprising:
- 0.001 to 15% by weight of an ester or a combination of esters of a vitamin-D compound according to one of formulae (I) to (IV):
- ##STR15## wherein R.sup.1 is selected from the group consisting of a C.sub.1-32 alkyl carbonyloxy, a C.sub.2-32 alkenyl carbonyloxy, a C.sub.2-32 alkapolyene carbonyloxy, a group of formula (V):
- ##STR16## a group of formula (VI):
- ##STR17## wherein n is 1, 2, 3, 4 or 5 and R.sup.2 is a radical selected from the group consisting of ##STR18## 0to 40% by weight of a solvent or solvent mixture which is pharmaceutically acceptable and is a hydrotropic or coemulsifier;
- 0.001 to 90% by weight of a pharmaceutically acceptable surfactant or surfactant mixture;
- and
- optionally up to 10% by weight of a vitamin or provitamin;
- and optionally up to 10% by weight of a free acid.
5 more elements
Dependencies are inferred from the claim text.