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OwnerNesbitt D. Brown, Bhupendra P. Doctor +1inventors
InventorsNesbitt D. Brown, Bhupendra P. Doctor, Joseph M. Marasco
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Storage-stable aqueous solutions of hydrolytically unstable organic ionic compounds and cyclodextrins, which cyclodextrins are capable of forming hydrolytically stable inclusion complexes with the ionic compounds. Storage-stable rapidly solvated organic ionic inclusion complexes of hydrolytically unstable organic ionic compounds and cyclodextrins, which cyclodextrins are capable of forming hydrolytically stable inclusion complexes with the ionic compounds. Systems for rapidly administering aqueous solutions effective in the treatment of organophosphorus toxin nerve poisoning to a mammal in need thereof combining a storage-stable aqueous solution of an inclusion complex of a hydrolytically unstable quaternary pyridinium oxime or aldoxime compound capable of reactivating carboxy, choline and esterases inhibited by the organophosphorus toxins and a cyclodextrin capable of forming a hydrolytically stable inclusion complex with the quaternary pyridinium compounds, and means for rapidly administering the aqueous solution. Systems for rapidly administering aqueous solutions effective in the treatment of organophosphorus toxin nerve poisoning combining the inclusion complex with means for rapidly solvating and administering the inclusion complex.
A storage-stable aqueous solution comprising an inclusion complex consisting essentially of a hydrolytically unstable water-soluble bis-quaternary pyridinium oxime with a cyclodextrin selected from the group consisting of alpha-cyclodextrins, beta-cyclodextrins and gamma-cyclodextrins, which cyclodextrin is capable of forming a hydrolytically stable inclusion complex with said bis-quaternary pyridinium oxime.
A storage-stable rapidly solvated inclusion complex consisting essentially of a hydrolytically unstable water-soluble bis-quaternary pyridinium oxime and a cyclodextrin selected from the group consisting of alpha-cyclodextrins, beta-cyclodextrins and gamma-cyclodextrins, which cyclodextrin is capable of forming a hydrolytically-stable inclusion complex with said bis-quaternary pyridinium oxime.
A system for rapidly administering an aqueous solution effective in the treatment of organophosphorus toxin poisoning to a mammal in need thereof, comprising:
A system for rapidly administering an aqueous solution effective in the treatment of organophosphorus toxin nerve poisoning to a mammal in need thereof, comprising:
Dependencies are inferred from the claim text.