Compositions and methods for preventing adhesion formation
AssigneeUniversity of Southern California
InventorsGere S. diZerega, Kathleen E. Rodgers
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Abstract
Compositions and methods for prevention of adhesion formation, whereby an effective amount of one or more adhesion preventing RGD-containing peptides is administered for a period of time sufficient to permit tissue repair. The RGD-containing peptide is further characterized in that it inhibits platelet aggregation and does not induce inflammation or trauma at the site of administration. The RGD-containing peptide is preferably administered in conjunction with a delivery vehicle (e.g., microcapsules, microspheres, liposomes, viscous instillates and absorbable mechanical barriers) useful for maintaining local concentrations of the peptide at an effective level.
Claims15
A method for preventing adhesion formation, comprising:
- Administering an effective amount of at least one RGD-containing peptide characterized by the sequence Arg-Gly-Asp-R, in which R is selected from the group consisting of Ser, Cys, Thr, Asn and d-Ser.
Dependencies are inferred from the claim text.