Use of angiotensin III and analogs thereof in tissue repair
AssigneeUniversity of Southern California
InventorsKathleen E. Rodgers, Gere S. DiZerega
Life of this patent
Estimating the term…
Abstract
Angiotensin III and analogs thereof are useful in accelerating wound healing. These analogs form the basis of compositions useful for accelerating wound healing, in which the active agent is present in an amount effective to accelerate wound healing. Preferably, the compositions are in the form of matrical or micellar solutions.
Claims16
A method of accelerating wound healing in mammals, comprising applying to a wound an amount effective to accelerate wound healing of at least one compound of general formula I
- R.sup.1 -R.sup.2 -R.sup.3 -R.sup.4 -R.sup.5 -R.sup.6 -R.sup.7
- in which R.sup.1 is selected from the group consisting of H, Arg, Lys, Ala, Orn, Ser(Ac), Sar, D-Arg and D-Lys;
- R.sup.2 is selected from the group consisting of Val, Ala, Leu, Ile, Gly, Pro, Aib, Acpc and Tyr;
- R.sup.3 is selected from the group consisting of Tyr, Thr, Ser and azaTyr;
- R.sup.4 is selected from the group consisting of Ile, Ala, Leu, Val and Gly;
- R.sup.5 is His or Arg;
- R.sup.6 is Pro or Ala;
- and
- R.sup.7 is selected from the group consisting of lie, Phe, Phe(Br) and Tyr.
A composition for accelerating wound healing in mammals, comprising a suitable carrier or diluent and an amount effective to accelerate wound healing of at least one compound of general formula I
- R.sup.1 -R.sup.2 -R.sup.3 -R.sup.4 -R.sup.5 -R.sup.6 -R.sup.7
- in which R.sup.1 is selected from the group consisting of H, Arg, Lys, Ala, Orn, Ser(Ac), Sar, D-Arg and D-Lys;
- R.sup.2 is selected from the group consisting of Val, Ala, Leu, lie, Gly, Pro, Aib, Acpc and Tyr;
- R.sup.3 is selected from the group consisting of Tyr, Thr, Ser and azaTyr;
- R.sup.4 is selected from the group consisting of lie, Ala, Leu, Val and Gly;
- R.sup.5 is His or Arg;
- R.sup.6 is Pro or Ala;
- and
- R.sup.7 is selected from the group consisting of lie, Phe, Phe(Br) and Tyr.
Dependencies are inferred from the claim text.