Cyclic peptide antifungal agents

A compound of the formula:

• ##STR35## wherein:
• R' is hydrogen, methyl or NH.sub.2 C(O)CH.sub.2 --;
• R" and R'" are independently methyl or hydrogen;
• R.sup.x1 is hydrogen, hydroxy or --O--R;
• R is C.sub.1 -C.sub.6 alkyl, benzyl, --(CH.sub.2).sub.2 Si(CH.sub.3).sub.3, --CH.sub.2 CHOHCH.sub.2 OH, --CH.sub.2 CH.dbd.CH.sub.2, --(CH.sub.2).sub.a COOH, --(CH.sub.2).sub.b NR.sup.z1 R.sup.z2, --(CH.sub.2).sub.c POR.sup.z3 R.sup.z4 or --[(CH.sub.2).sub.2 O].sub.d --(C.sub.1 -C.sub.6)alkyl;
• a, b and c are independently 1, 2, 3, 4, 5 or 6;
• R.sup.z1 and R.sup.z2 are independently hydrogen, C.sub.1 -C.sub.6 alkyl, or R.sup.z1 and R.sup.z2 combine to form-CH.sub.2 (CH.sub.2)eCH.sub.2 --;
• R.sup.z3 and R.sup.z4 are independently hydroxy or C.sub.1 -C.sub.6 alkoxy;
• d is 1 or 2;
• e is 1, 2 or 3;
• R.sup.x2, R.sup.y1, R.sup.y2, R.sup.y3 and R.sup.y4 are independently hydrogen or hydroxy;
• R.sup.0 is hydroxy, --OP(O)(OH).sub.2 or a group of the formulae:
• ##STR36## R.sup.1 is C.sub.1 -C.sub.6 alkyl, phenyl, p-halo-phenyl, p-nitrophenyl, benzyl, p-halo-benzyl or p-nitro-benzyl;
• R.sup.2 is ##STR37## R.sup.3 is ##STR38## R.sup.3a is C.sub.1 -C.sub.6 alkoxy;
• R.sup.3b and R.sup.3c are independently phenyl or naphthyl;
• R.sup.3d is C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkoxy or --O--(CH.sub.2).sub.m --[O--(CH.sub.2).sub.n ].sub.p --O--(C.sub.1 -C.sub.12 alkyl);
• m is 2, 3 or 4;
• n is 2, 3 or 4;
• and
• p is 0 or 1;
• or a pharmaceutically acceptable salt thereof.