ETS1 gene: a human tumor suppressor gene
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsHiroaki Suzuki, Narayan K. Bhat, Takis S. Papas
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Abstract
The present invention relates, in general, to methods for reducing cell tumorigenicity. More particularly, the present invention provides a method for reducing cell tumorigenicity comprising transfecting a tumor cell with an ETS1 gene, the tumor cell not endogenously expressing the ETS1 gene. In addition, the present invention provides a method for reducing cell tumorigenicity comprising contacting a tumor cell with a peptide expressed by an ETS1 gene, the tumor cell not endogenously expressing the ETSI gene. The methods of the present invention are particularly useful for reducing tumorigenicity in epithelial tumor cells.
Claims6
A method of reducing the tumorigenicity of a cell in vitro, said cell not endogenously expressing an ETS1 gene, said method comprising:
- transfecting said cell with an ETS1 gene so that the transfected ETS1 gene is expressed, whereby the tumorigenicity of said cell is reduced.
Dependencies are inferred from the claim text.