Process for disintegrating cell dispersions or cell suspensions by means of ultrasonication for the purpose of isolating cell constituents

Process for disintegrating a cell dispersion or a cell suspension by means of ultrasonication treatment in an ultrasonication flow-through cell having an acoustic irradiation vessel for the purpose of obtaining cell constituents, said process comprising the steps of

• projecting a sonotrode into the flow-through cell wherein 1/2 to 2/3 of a length of the sonotrode is projected into the flow through cell and acoustic irradiation vessel and immersed in a medium to be sonicated, said vessel having a surface therein directly opposite the sonotrode, wherein an angle of the sonotrode in the acoustic irradiation vessel, relative to said surface, is within the range of from 80.5.degree. to 88.5.degree., wherein the ratio of the extent of immersion of the sonotrode (in mm) to an acoustic irradiation volume (in ml) in the vessel is set to a value within the range from 1:1.1 to 1:20 and wherein the ratio of the extent of immersion of the sonotrode (in mm) to the proportion of solid matter in the medium to be sonicated (in percent by weight) is within the range from 1:0.02 to 1:2.2;
• and
• flowing a cell dispersion or cell suspension through the irradiation vessel and sonicating the cell dispersion or cell suspension.