Method of identifying agents which modulate ICAM-3 binding to LFA-1
AssigneeCenter for Blood Research, Inc.
InventorsAntonin R. deFougerolles, Timothy A. Springer
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Abstract
The present invention relates to intercellular adhesion molecules (ICAM-3) which is involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes therapeutic and diagnostic uses for adhesion molecules and for the antibodies that are capable of binding them.
Claims17
A method of identifying agents capable of antagonizing ICAM-3 binding to LFA-1, comprising the steps of:
- contacting ICAM-3 with LFA-1 in the presence of a compound;
- measuring ICAM-3/LFA-1 binding in the presence of said compound;
- wherein decreased binding compared to binding in the absence of said compound identifies said compound as an antagonist of ICAM-3 binding to LFA-1.
A method of identifying agents capable of agonizing ICAM-3 binding to LFA-1, comprising the steps of:
- contacting ICAM-3 with LFA-1 in the presence of a compound;
- measuring ICAM-3/LFA-1 binding in the presence of said compound;
- wherein increased binding compared to binding in the absence of said compound identifies said compound as an agonist of ICAM-3 binding to LFA-1.
Dependencies are inferred from the claim text.