Modified amino acids for drug delivery
AssigneeEmisphere Technologies, Inc.
InventorsAndrea Leone-Bay, Nai F. Wang
Life of this patent
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Abstract
The present invention relates to an oral delivery system, and in particular to modified amino acids or peptides for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids or peptides can form non-covalent mixtures or microspheres with active biological agents. These mixtures or microspheres are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids and peptides are also disclosed.
Claims29
A composition comprising:
- (A) at least one biologically active agent selected from the group consisting of a peptide, a mucopoly-saccharide, a carbohydrate, a lipid, a pesticide, or any combination thereof, and
- (B)
- (a) at least one acylated amino acid;
- (b) at least one peptide comprising at least one acylated amino acid;
- or
- (c) a combination of (a) and (b);
- wherein said acylated amino acid is acylated by
- a C.sub.3 -C.sub.10 cycloalkyl acylating agent.
A composition comprising:
- (A) at least one biologically active agent selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon,interleukin-II insulin, heparin, calcitonin, erythropoietin, atrial naturetic factor, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, cromolyn sodium, vancomycin, desferrioxamine (DFO), or any combination therof, and
- (B)
- (a) at least one acylated amino acid;
- (b) at least one peptide comprising at least one acylated amino acid;
- or
- (c) a combination of (a) and (b);
- wherein said acylated amino acid is acylated by
- a C.sub.3 -C.sub.10 cycloalkyl acylating agent.
A method for preparing a composition, said method comprising mixing:
- (A) at least one biologically-active agent selected from the group consisting of a peptide, a mucopoly-saccharide, a carbohydrate, a lipid, a pesticide, or any combination thereof;
- (B)
- (a) at least one acylated amino acid;
- (b) at least one peptide comprising at least one acylated amino acid;
- or
- (c) a combination of (a) and (b);
- wherein said acylated amino acid is acylated by
- a C.sub.3 -C.sub.10 cycloalkyl acylating agent;
- and
- (C) optionally a dosing vehicle.
Dependencies are inferred from the claim text.