Composition for controlled release of an active substance and method for the preparation of such a composition
AssigneeNederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
InventorsArie C. Besemer, Jan P. Van Der Lugt
Life of this patent
Estimating the term…
Abstract
In a composition for delayed release of an active substance, the active substance is incorporated in a polysaccharide matrix which consists of an essentially crystalline straight-chain glucan and contains a glucan-degrading agent. The glucan is in particular an .alpha.-glucan which has essentially a helix structure. The glucan-degrading agent is preferably .alpha.-amylase. The composition can contain high-molecular materials such as proteins, allergens, vaccine substances and microorganisms, and preferably has the form of compressed tablets.
Claims16
A composition for the delayed release of an active substance, the active substance being present in an amount of 0.01-80% by weight of the composition and being incorporated in a polysaccharide matrix, the matrix comprising at least 35% by weight of a crystalline straight-chain .alpha.-glucan having a helix structure, and a glucan-degrading agent present in the amount of 0.05-15% by weight of the composition.
A composition for the delayed release of an active substance being a compound, the active substance having a molecular weight of more than 1,500 dalton and being present in an amount of 0.01-80% by weight of the composition and being incorporated in a polysaccharide matrix, the matrix comprising at least 35% by weight of a crystalline straight-chain .alpha.-glucan having a helix structure, and a glucan-degrading agent.
A composition for the delayed release of an active substance, the active substance being a protein or a microorganism and being present in an amount of 0.01-80% by weight of the composition and being incorporated in a polysaccharide matrix, the matrix comprising at least 35% by weight of a crystalline straight-chain .alpha.-glucan having a helix structure, and a glucan-degrading agent.
A method for the preparation of a composition for the delayed release of an active substance, the active substance being incorporated in a polysaccharide matrix and the matrix comprising at least 35% by weight of a crystalline straight-chain .alpha.-glucan having a helix structure, and a glucan-degrading agent, the method comprising granulating said .alpha.-glucan and mixing the granulated said .alpha.-glucan, before or after granulating, with said active substance and the glucan-degrading agent such that the active substance is present in the amount of 0.01-80% by weight of the composition, and then bringing the granulated mixture to a desired form.
Dependencies are inferred from the claim text.