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US 5,629,009 AGranted
Delivery system for controlled release of bioactive factors
AssigneeMassachusetts Institute of Technology
InventorsCato T. Laurencin, Paul A. Lucas, Glenn T. Syftestad, Abraham Domb, Julie Glowacki, Robert S. Langer
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Abstract
A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble proteins at a rate which allows them to interact with local cell populations.
Claims9
A method of inducing chondrogenesis and osteogenesis in an animal comprising implanting in the animal a delivery device comprising:
- a. a shaped matrix sized and adapted for administration of the bioactive substance to an animal and formed of a polymer selected from the group consisting of polyanhydride and polyorthoester;
- and
- b. a therapeutically effective amount of a bioactive substance selected from the group consisting of water soluble chondrogenic or osteogenic proteins derived from demineralized bone matrix, TGF-beta, EGF, FGF and PDGF, wherein the bioactive substance is present in an amount of between about 10 and 90 percent by weight of matrix;
- wherein the composition erodes at a controlled rate over a period of time, thereby administering the bioactive substance to the animal in an amount effective to induce formation of cartilage and bone or wound healing.
1 more element
Dependencies are inferred from the claim text.