Oral administration of therapeutic proteins for treatment of infectious disease
AssigneeUniversity of Cincinnati
InventorsJ. Gabriel Michael, Allen Litwin
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Abstract
An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process.
Claims20
An orally administrable immunogenic composition for activating the immune system of a warm-blooded animal comprising:
- at least one immunogen of a microbial organism infectious for said warm-blooded animal microencapsulated in the complete absence of organic solvents with a water based enteric coating.
An orally administrable immunogenic composition for activating the immune system of a warm-blooded animal comprising:
- at least one immunogen therapeutic for said warm-blooded animal microencapsulated in the complete absence of organic solvents with a water based enteric coating.
An orally administrable immunogenic composition for activating the immune system of a warm-blooded animal comprising:
- at least one immunogen therpeutic for said warm-blooded animal microencapsulated in the complete absence of organic solvents with a water based enteric coating, wherein
- said immunogen is microencapsulated on particles of a pharmaceutically inert material with
- a first coating comprising
- said immunogen,
- lactose or trehalose, and
- polyvinylpyrrolidone, and
- a second coating comprising
- said enteric coating and
- triethyl citrate.
Dependencies are inferred from the claim text.