Formulations of oral gastrointestinal diagnostic x-ray contrast agents and oral gastrointestinal therapeutic agents
AssigneeNano Systems L.L.C.
InventorsGary Liversidge, W. Mark Eickhoff, Kathleen J. Illig, Pramod Sarpotdar, Stephen B. Ruddy
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Abstract
Nanoparticulate crystalline x-ray contrast agents are formulated with stabilizers to enhance contact between the crystalline x-ray contrast agents and the gastrointestinal tract. Nanoparticulate crystalline therapeutic substances also formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the gastrointestinal tract and to provide extended therapeutic effect.
Claims10
An orally/rectally administrable gastrointestinal diagnostic x-ray contrast formulation comprising:
- a--of from about 4 to about 45% w/v of an essentially water-insoluble particulate radiopaque crystalline material having an effective average particle size of less than about 2,000 nm;
- b--of from about 0.1 to about 10% w/v of a bioadhesive surfactant stabilizer selected form the group consisting of:
- (i) polyethylene-polypropylene glycol block polymers of the formula
- (polyethylene oxide).sub.a -(polypropylene oxide).sub.b -(polyethylene oxide).sub.c
- wherein
- a is 46 to 128;
- b is 16 to 67;
- and
- c is 46 to 128;
- and
- c--water to make 100% w/v.
A method of carrying out x-ray examination of the gastrointestinal tract of a patient, said method comprises the oral/rectal administration to the patient an x-ray contrast composition comprising:
- a--of from about 4 to about 45% w/v of an essentially water-insoluble particulate radiopaque crystalline material having an effective average particle size of less than about 2,000 nm;
- b--of from about 0.1 to about 10% w/v of a bioadhesive surfactant stabilizer selected form the group consisting of:
- (i) polyethylene-polypropylene glycol block polymers of the formula
- (polyethylene oxide).sub.a -(polypropylene oxide).sub.b -(polyethylene oxide).sub.c
- wherein
- a is 46 to 128;
- b is 16 to 67;
- and
- c is 46 to 128;
- and
- c--water to make 100% w/v.
Dependencies are inferred from the claim text.