Stabilization of fluorocarbon emulsions
AssigneeAlliance Pharmaceutical Corp.
InventorsJeffry G. Weers, David H. Klein, Cindy S. Johnson
Life of this patent
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Abstract
Storage stable fluorocarbon emulsions having a continuous aqueous phase and a discontinuous fluorocarbon phase, in which the fluorocarbon phase comprises a major amount of a first fluorocarbon or fluorocarbon mixture, and a minor amount of a second fluorocarbon or fluorocarbon mixture, in which the second fluorocarbon has a molecular weight greater than that of the first fluorocarbon and the second fluorocarbon includes a lipophilic moiety in its structure, whereby the second fluorocarbon serves to promote particle size stability in the emulsion while simultaneously providing favorably short organ retention times when administered to animals in vivo.
Claims34
A storage stable fluorocarbon emulsion, comprising:
- a continuous aqueous phase;
- an effective emulsifying amount of an emulsifying agent;
- and
- a discontinuous fluorocarbon phase, comprising from about 60% to about 99.9% of one or more first fluorocarbons having a molecular weight from about 448 to about 550 daltons, and from about 0.1% to about 40% of one or more second fluorocarbons having a molecular weight greater than or equal to about 540 daltons, the molecular weight of each second fluorocarbon being greater than each said first fluorocarbon, wherein each said second fluorocarbon is an aliphatic fluorocarbon substituted with at least one lipophilic moiety selected from the group consisting of Br, Cl and I and H.
A method for imparting particle size stability to a fluorocarbon emulsion having a discontinuous phase of a major amount of one or more first fluorocarbons having a molecular weight from about 460 to about 550 Daltons and a continuous aqueous phase, comprising the step of including in admixture with said first fluorocarbon a minor emulsion-stabilizing amount of one or more second fluorocarbons having a molecular weight greater than said first fluorocarbon wherein each said second fluorocarbon is an aliphatic fluorocarbon substituted with a lipophilic moiety selected from the group consisting of Br, Cl, I and H.
Dependencies are inferred from the claim text.