Glycolipids, their preparation and use
AssigneeGenzyme Corporation
InventorsSabine L. Flitsch, Benedicte Guilbert
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Abstract
A process for preparing a glycolipid of formula (I): [(sac).sub.m+n ]--O--CH.sub.2 --CHX--CH(OQ)--Y wherein Q is H or a blocking group; X is N.sub.3 or NH.sub.2 ; Y is a lipid residue; each sac is a saccharide; and m and n are each integers; comprises reacting a corresponding glycolipid of formula (II): (sac).sub.n --O--CH.sub.2 --CHX--CH(OQ)--Y with the corresponding saccharide (sac).sub.m or a reactive derivative thereof, in the presence of an enzyme that catalyses the reaction. Compounds of formulae (I) and (II) are suitable for elaboration to a variety of saccharide ceramides.
Claims13
A process for preparing a glycolipid of formula I
- [(sac).sub.m+n ]--O--CH.sub.2 --CHX--CH(OQ)--Y
- wherein Q is H or a blocking group;
- X is N.sub.3 or NH.sub.2 ;
- Y is a lipid residue;
- each sac is a saccharide;
- and m and n are each integers;
- which comprises reacting a corresponding glycolipid of formula II
- (sac).sub.n --O--CH.sub.2 --CHX--CH(OQ)--Y
- with the corresponding saccharide (sac).sub.n or a reactive derivative thereof, in the presence of an enzyme that catalyses the reaction.
Dependencies are inferred from the claim text.