Method and composition for the treatment of septic shock
AssigneeThe Board of Regents of the University of Oklahoma
InventorHeloise A. Pereira
Life of this patent
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Abstract
The present invention contemplates a composition and method for treating septic shock in a mammal or as a prophylactic treatment prior to a surgical procedure, comprising administering a therapeutically effective amount of a bacterial lipopolysaccharide binding peptide derived from CAP37 protein. In a preferred version, the composition and method of use may comprise a peptide comprising amino acids 20-44 or 120-146 of CAP37 or subunits thereof.
Claims11
A peptide capable of binding bacterial lipopolysaccharide, comprising the amino acid sequence as defined in the Sequence Listing of SEQ ID NO:3.
A DNA molecule comprising a nucleotide sequence encoding a peptide having the amino acid sequence set forth in SEQ ID NO:3, wherein said encoded peptide effectively binds to bacterial lipopolysaccharide.
A composition for treating septic shock in a mammal, comprising a therapeutically effective amount of a peptide having the amino acid sequence as defined in the Sequence Listing of SEQ ID NO:3.
A method for treating septic shock in a mammal, comprising administering to the mammal a therapeutic composition comprising a pharmacologically effective amount of a bacterial lipopolysaccharide binding peptide having the amino acid sequence as defined in the Sequence Listing by SEQ ID NO:3.
A method of prophylactic treatment for minimizing septic shock in a mammal, comprising administering to the mammal a therapeutic composition comprising a pharmacologically effective amount of a lipopolysaccharide binding peptide having the amino acid sequence set forth in SEQ ID NO:3.
A method of treating physiological effects caused by bacterial lipopolysaccharide in a mammal, comprising administering to the mammal a therapeutic composition comprising a pharmacologically effective amount of a peptide having the amino acid sequence as defined in the Sequence Listing by SEQ ID NO:3.
A method of treating a mammal for the effects of bacterial lipopolysaccharide on systemic vascular resistance, cardiac output, tissue perfusion and white blood cell count, comprising administering to the mammal a therapeutic composition comprising a pharmacologically effective amount of a peptide having the amino acid sequence as defined in the Sequence Listing by SEQ ID NO:3.
A method of mediating the effects of a bacterial lipopolysaccharide-induced endotoxic response in a test animal, comprising:
- providing a test animal;
- administering a predetermined amount of endotoxin to the test animal;
- and
- administering a predetermined amount of CAP37 peptide 120-146 to the test animal.
A method for treating infection at a particular tissue site in an animal, comprising the step of applying to the tissue site a topical medication comprising an antibiotic peptide having the amino acid sequence set forth in SEQ ID NO:3, wherein the peptide is present in the medication at a pharmacologically effective amount to treat infection.
A method for treating infection in animals, comprising the step of administering to the animal a therapeutic composition comprising a pharmacologically effective amount of an antibiotic peptide comprising the sequence as defined in SEQ ID NO:3.
Dependencies are inferred from the claim text.