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US 5,627,215 AGranted
Unsaturate amino compounds for use as anticancer and antiprotozoic agent
AssigneeCiba-Geigy Corporation
InventorsJorg Frei, Jaroslav Stanek
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AssigneeCiba-Geigy Corporation
InventorsJorg Frei, Jaroslav Stanek
Estimating the term…
The invention relates to compounds of formula (I), R.sub.1 and R.sub.2, each independently of the other, are selected from lower alkyl that is unsubstituted or substituted by one or more fluorine atoms which are not linked to the carbon atom of R.sub.1 or R.sub.2 bonding the nitrogen; from lower alkenyl wherein the double bond does not originate from the carbon atom that is bonded to a nitrogen bonding R.sub.1 or R.sub.2 ; from lower alkynyl wherein the triple bond does not originate from the carbon atom that is bonded to a nitrogen bonding R.sub.1 or R.sub.2 ; from cycloalkyl; and from cycloalkyl-lower alkyl; with the proviso that not more than one of the two radicals R.sub.1 and R.sub.2 is methyl; or salts thereof. The mentioned compounds are pharmacologically active against disorders that are responsive to a recuction in intracellular polyamines, such as tumours or protozoal diseases.
A compound of formula I, ##STR9## wherein R.sub.1 and R.sub.2, each independently of the other, are selected from C.sub.2 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl wherein the double bond does not originate from the carbon atom that is bonded to a nitrogen bonding R.sub.1 or R.sub.2, and from C.sub.3 -C.sub.4 cycloalkylmethyl, or a salt thereof.
Dependencies are inferred from the claim text.