Heterocyclic amides
AssigneeHafslund Nycomed Pharma Aktiengesellschaft
InventorsPeter Esch, Robertson Towart, Franz Rovenszky
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Abstract
The invention relates to heterocyclic amides of the formula ##STR1## in which the radicals A, Z, A.sub.1, R.sub.1, R.sub.2 and R.sub.3 are as defined in the description, to a process for the preparation of these amides and to their use as active substances for the curing and amelioration of disorders and diseases which can be treated by exerting influence on potassium channels.
Claims12
A heterocyclic amide of the formula I ##STR9## in which A is an aromatic or S- or N-heteroaromatic ring having 5-10 carbon atoms which can be unsubstituted or mono- or polysubstituted by straight-chain or branched C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxyl, halogen or CF.sub.3, CF.sub.3 CF.sub.2, Z is a radical C.dbd.O, SO or SO.sub.2,
- A.sub.1 is a heteroaromatic system of the formula IIa-IIc ##STR10## or a heteroaromatic system of the formula IIIa-IIIc ##STR11## R.sub.1 and R.sub.2 independently of one another are H, straight-chain or branched (C.sub.1 -C.sub.4)-alkyl or fluorinated alkyl, and R.sub.3 is H, straight-chain or branched (C.sub.1 -C.sub.4)-alkyl, acetyl, alkylacetyl or a group which can be eliminated under physiological conditions.
N-[5-(Phenylsulfonyl)-thien-2-yl]-3,3,3-tri-fluoro-2-hydroxy -2-methylpropanamide.
A process for the preparation of a compound of the formula I ##STR12## which comprises coupling a compound of the formula IV
- A--Z--A.sub.1 --NH.sub.2 IV
- with the aid of known coupling reagents, with a compound of the formula V ##STR13## and, if appropriate, separating the resulting mixture of optical isomers into the enantiomers.
Dependencies are inferred from the claim text.