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US 5,627,197 AGranted
Adhesion receptor antagonists
AssigneeMerck Patent GmbH
InventorsJoachim Gante, Horst Juraszyk, Peter Raddatz, Hanns Wurziger, Sabine Bernotat-Danielowski, Guido Melzer
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Abstract
Compounds of the formula I ##STR1## wherein R.sup.1 and Y have the meanings indicated herein, and also their physiologically acceptable salts, inhibit the binding of fibrinogen to the corresponding receptor and can be employed for the treatment of thromboses, osteoporoses, oncoses, apoplexy, cardiac infarct, inflammations, arteriosclerosis and osteolytic disorders.
Claims26
A compound of formula I ##STR9## wherein X is O, S, NH or NA;
- Y is ##STR10## R.sup.1 is ##STR11## R.sup.2 and R.sup.3 are, in each case independently of one another, H, A or benzyl;
- A is alkyl having 1 to 6 C atoms;
- B is H, A, benzyl or amidino;
- D is amidino, aminomethyl, aminohydroxyiminomethyl, 5-oxo-1,2,4-oxadiazolin-3-yl, 5-methyl-1,2,4-oxadiazolin-3-yl or guanidinomethyl;
- m, r and s are, in each case independently of one another, 0, 1, 2, 3 or 4;
- and
- n is 2, 3 or 4;
- wherein each free amino or amidino group is optionally protected by an amino protective group;
- or
- a physiologically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.