US 5,627,194 A · Anti-viral guanidino-substituted compounds

Abstract

Novel guanidino-substituted compounds are described having the following general formula (I): ##STR1## in which X may be carbon, oxygen, nitrogen or sulfur; R.sub.1 may be H, OH, linear or branched lower alkyl, lower alkoxy, lower (alkyl-substituted alkoxy), lower alkyl-amine, lower alkyl-thio, hydroxy substituted lower alkoxy, lower alkoxy-alkoxy substituted lower alkoxy, hydroxy substituted lower alkyl-amine, alkoxy substituted lower alkyl-amine and terminally guanidino-substituted linear of branched lower alkyl, lower alkoxy, lower (alkyl-substituted alkoxy), lower alkyl-amine or lower alkyl-thio; and R.sub.2 and R.sub.3 are independently one of linear or branched lower alkyl, alkoxy, alkyl-substituted alkoxy and alkylamine. These compounds have been found to inhibit effectively herpesvirus replication. Particularly preferred compounds in accordance with formula (I) for this purpose are guanidino-substituted sugar derivatives.

Claims19

Dependent claims

A compound of formula (I):

##STR7## or a salt thereof, wherein X is selected from C, O, N and S;
R.sub.1 is selected from H, OH, and linear or branched lower alkyl, lower alkoxy, lower (alkyl-substituted alkoxy), lower alkyl-amine, lower alkyl-thio, hydroxy substituted lower alkoxy, lower alkoxy-alkoxy substituted lower alkoxy, hydroxy substituted lower alkyl-amine, alkoxy substituted lower alkyl-amine and terminally guanidino-substituted linear or branched lower alkyl, lower alkoxy, lower (alkyl-substituted alkoxy), lower alkyl-amine or lower alkyl-thio;
and
R.sub.2 and R.sub.3 are independently selected from linear or branched lower alkylene in which one of the carbon atoms thereof is optionally replaced by an atom selected from nitrogen or oxygen.

1 more element

Dependencies are inferred from the claim text.

Anti-viral guanidino-substituted compounds

Life of this patent

Anti-viral guanidino-substituted compounds

Life of this patent

Abstract

Claims19