Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds
AssigneeMitsui Toatsu Chemicals, Inc.
InventorsJunya Fujiwara, Haruki Mori, Hiroyuki Yamashita, Takashi Kitamori, Junko Hosoya, Hitoshi Banno
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Abstract
The present invention relates to quinoline-4-carbonylguanidine derivative represented by formula (1) ##STR1## and pharmaceutically acceptable salt thereof, a process for producing the same, and a Na.sup.+ /H.sup.+ exchanger inhibitor containing the compound as an active ingredient. The compounds of the present invention are useful as an agent for treating or preventing various diseases by hyperfunction of the Na.sup.+ /H.sup.+ exchanger and as a diagnostic agent for these diseases.
Claims27
A quinoline-4-carbonylguanidine derivative represented by formula (1) ##STR5## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and each represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a halogen atom, a nitro group, an amino group, a hydroxyl group, an alkyloxy group having from 1 to 6 carbon atoms, an alkyloxy group having from 1 to 6 carbon atoms and containing a terminal alkyloxy group having from 1 to 6 carbon atoms, an alkylsulfonylamino group having from 1 to 6 carbon atoms, or an alkanoylamino group having from 2 to 6 carbon atoms,
- X.sup.1, X.sup.2, X.sup.3, X.sup.4 and X.sup.5 are the same or different and each represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a halogen atom, a nitro group, an amino group, a hydroxyl group, a trifluoromethyl group, an alkyloxy group having from 1 to 6 carbon atoms, an alkyloxy group having from 1 to 6 carbon atoms and containing a terminal alkyloxy group having from 1 to 6 carbon atoms, or
- a trifluoromethoxy group, and
- Y represents a hydrogen atom, or an alkyl group having from 1 to 6 carbon atoms,
- or a pharmaceutically acceptable salt thereof.
An agent for treating or preventing organ disorders caused by ischemia in a surgical operation or transplantation of internal organs, said agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim i.
Dependencies are inferred from the claim text.