Antihyperlipidemic/antioxidant dihydroquinolines
AssigneeBristrol-Myers Squibb Company
InventorsBradley C. Pearce, John J. Wright
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Abstract
The present invention relates to novel dihydroquinolines which are useful for cholesterol lowering and as antioxidant agents. Also provided is a process for preparing the dihydroquinolines of the present invention, pharmaceutical compositions, and a method of treating or inhibiting hypercholesterolemia, hyperlipidemia, atherosclerosis, and LDL oxidation which comprises administering to birds and mammals in need of such treatment an effective amount of a compound of the present invention.
Claims2
A method of inhibiting cholesterol biosynthesis, lowering LDL cholesterol, and inhibiting LDL oxidation which comprises administering to a host in need thereof an effective amount of a compound having the formula ##STR13## wherein X is O, S or Ch.sub.2
- R.sup.1 is H or ##STR14## R.sup.2 and R.sup.3 are independently H, C.sub.1 -C.sub.5 alkyl, CF.sub.3, CN, halogen or OCH.sub.3,
- n is an integer of 1 to 3, and
- m is an integer of 1 to 3, or
- a pharmaceutically acceptable salt thereof.
A method of treating hypercholesterolemia, hyperlipidemia and atherosclerosis which comprises administering to a host in need thereof an effective amount of a compound having the formula ##STR15## wherein X is O, S or Ch.sub.2
- R.sup.1 is H or ##STR16## R.sup.2 and R.sup.3 are independently H, C.sub.1 -C.sub.5 alkyl, CF.sub.3, CN, halogen or OCH.sub.3,
- n is an integer of 1 to 3, and
- m is an integer of 1 to 3, or
- a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.