Antiviral combinations
AssigneeGlaxo Group Limited
InventorsJanet M. Cameron, Nicholas Cammack
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Abstract
Combinations comprising a compound of formula (1) ##STR1## or a pharmaceutically acceptable derivative thereof and an inhibitor of HIV replication, pharmaceutical formulations thereof and their use in the treatment of HIV infections.
Claims6
A combination of drugs which are active against HIV wherein said combination comprises a mixture of first and second compounds wherein said first compound is (2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-1H-pyrimidin-2-on e or a pharmaceutically acceptable salt, ester or salt of said ester of said first compound and said second compound is 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable salt, ester or salt of said ester of said second compound;
- said first and second compounds being in a ratio which is synergistic against HIV wherein the ratio of said first compound to said second compound is from about 1.8:1 to about 167:1 by weight.
A method for the treatment of a mammal, including man, suffering from or susceptible to infection by HIV comprising administration of first and second compounds wherein first compound is (2R,cis)-4-amino-1-(2hydroxymethyl-1,3-oxathiolan-5-yl)-1H-pyrimidin-2-one or a pharmaceutically acceptable salt, ester or salt of said ester of said first compound and said second compound is 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable salt, ester or salt of said ester of said second compound in a ratio of said first compound to said second compound which is about 1.8:1 to 167:1.
Dependencies are inferred from the claim text.